Augmentation of Vα14 Nkt Cell–Mediated Cytotoxicity by Interleukin 4 in an Autocrine Mechanism Resulting in the Development of Concanavalin a–Induced Hepatitis

The administration of concanavalin A (Con A) induces a rapid severe injury of hepatocytes in mice. Although the Con A–induced hepatitis is considered to be an experimental model of human autoimmune hepatitis, the precise cellular and molecular mechanisms that induce hepatocyte injury remain unclear....

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Main Authors: Kaneko, Yoshikatsu, Harada, Michishige, Kawano, Tetsu, Yamashita, Masakatsu, Shibata, Youichi, Gejyo, Fumitake, Nakayama, Toshinori, Taniguchi, Masaru
Formato: Artigo
Idioma:Inglês
Publicado: The Rockefeller University Press 2000
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2195789/
https://ncbi.nlm.nih.gov/pubmed/10620609
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