The Plasminogen Activator Inhibitor PAI-1 Controls in Vivo Tumor Vascularization by Interaction with Proteases, Not Vitronectin: Implications for Antiangiogenic Strategies

The plasminogen (Plg)/plasminogen activator (PA) system plays a key role in cancer progression, presumably via mediating extracellular matrix degradation and tumor cell migration. Consequently, urokinase-type PA (uPA)/plasmin antagonists are currently being developed for suppression of tumor growth...

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Bibliografiska uppgifter
Huvudupphovsmän: Bajou, Khalid, Masson, Véronique, Gerard, Robert D., Schmitt, Petra M., Albert, Valérie, Praus, Michael, Lund, Leif R., Frandsen, Thomas L., Brunner, Nils, Dano, Keld, Fusenig, Norbert E., Weidle, Ulrich, Carmeliet, Geert, Loskutoff, David, Collen, Desiré, Carmeliet, Peter, Foidart, Jean Michel, Noël, Agnès
Materialtyp: Artigo
Språk:Inglês
Publicerad: The Rockefeller University Press 2001
Ämnen:
Original Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2195770/
https://ncbi.nlm.nih.gov/pubmed/11266468
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