Defects in Hemopoietic Stem Cell Activity in Ikaros Mutant Mice

Here we provide evidence that the Ikaros family of DNA binding factors is critical for the activity of hemopoietic stem cells (HSCs) in the mouse. Mice homozygous for an Ikaros null mutation display a >30-fold reduction in long-term repopulation units, whereas mice homozygous for an Ikaros domina...

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Main Authors: Nichogiannopoulou, Aliki, Trevisan, Maryanne, Neben, Steve, Friedrich, Christoph, Georgopoulos, Katia
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 1999
Teme:
Original Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2195677/
https://ncbi.nlm.nih.gov/pubmed/10544193
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