The Stimulation of Low-Affinity, Nontolerized Clones by Heteroclitic Antigen Analogues Causes the Breaking of Tolerance Established to an Immunodominant T Cell Epitope

H-2K mice injected, intravenously in saline or intraperitoneally in incomplete Freund's adjuvant, with large quantities of the immunodominant I-E(k)–restricted epitope from moth cytochrome c (MCC) 88–103 fail to respond to subsequent immunization with this epitope when administered in complete...

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Autores principales: Wang, Rongfang, Wang-Zhu, Yiran, Gabaglia, Claudia Raja, Kimachi, Kazuhiko, Grey, Howard M.
Formato: Artigo
Lenguaje:Inglês
Publicado: The Rockefeller University Press 1999
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2195641/
https://ncbi.nlm.nih.gov/pubmed/10510088
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