Combination Immunotherapy of B16 Melanoma Using Anti–Cytotoxic T Lymphocyte–Associated Antigen 4 (Ctla-4) and Granulocyte/Macrophage Colony-Stimulating Factor (Gm-Csf)-Producing Vaccines Induces Rejection of Subcutaneous and Metastatic Tumors Accompanied by Autoimmune Depigmentation

We examined the effectiveness of cytotoxic T lymphocyte–associated antigen 4 (CTLA-4) blockade, alone or in combination with a granulocyte/macrophage colony-stimulating factor (GM-CSF)–expressing tumor cell vaccine, on rejection of the highly tumorigenic, poorly immunogenic murine melanoma B16-BL6....

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Bibliographic Details
Main Authors: van Elsas, Andrea, Hurwitz, Arthur A., Allison, James P.
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 1999
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2195583/
https://ncbi.nlm.nih.gov/pubmed/10430624
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