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Epithelial expression of TLR4 is modulated in COPD and by steroids, salmeterol and cigarette smoke

The toll-like receptors (TLRs) are a key component of host defense in the respiratory epithelium. Cigarette smoking is associated with increased susceptibility to infection, while COPD is characterised by bacterial colonisation and infective exacerbations. We found reduced TLR4 gene expression in th...

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Bibliografiske detaljer
Main Authors: MacRedmond, Ruth E, Greene, Catherine M, Dorscheid, Delbert R, McElvaney, Noel G, O'Neill, Shane J
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2007
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2194695/
https://ncbi.nlm.nih.gov/pubmed/18034897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1465-9921-8-84
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