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Tamoxifen Neuroprotection in Cerebral Ischemia Involves Attenuation of Kinase Activation and Superoxide Production and Potentiation of Mitochondrial Superoxide Dismutase

The purpose of this study was to enhance our understanding of the mechanisms of neuronal death after focal cerebral ischemia and the neuroprotective effects of tamoxifen (TMX). The phosphorylation state of 31 protein kinases/signaling proteins and superoxide anion (O(2)(−)) production in the contral...

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Détails bibliographiques
Auteurs principaux: Wakade, Chandramohan, Khan, Mohammad M., De Sevilla, Liesl M., Zhang, Quan-Guang, Mahesh, Virendra B., Brann, Darrell W.
Format: Artigo
Langue:Inglês
Publié: The Endocrine Society 2008
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2194601/
https://ncbi.nlm.nih.gov/pubmed/17901229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2007-0899
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