Distinct Mutations in IRAK-4 Confer Hyporesponsiveness to Lipopolysaccharide and Interleukin-1 in a Patient with Recurrent Bacterial Infections

We identified previously a patient with recurrent bacterial infections who failed to respond to gram-negative LPS in vivo, and whose leukocytes were profoundly hyporesponsive to LPS and IL-1 in vitro. We now demonstrate that this patient also exhibits deficient responses in a skin blister model of a...

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Autori principali: Medvedev, Andrei E., Lentschat, Arnd, Kuhns, Douglas B., Blanco, Jorge C.G., Salkowski, Cindy, Zhang, Shuling, Arditi, Moshe, Gallin, John I., Vogel, Stefanie N.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Rockefeller University Press 2003
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2194174/
https://ncbi.nlm.nih.gov/pubmed/12925671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20030701
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