Cutaneous Immunization Rapidly Activates Liver Invariant Vα14 NKT Cells Stimulating B-1 B Cells to Initiate T Cell Recruitment for Elicitation of Contact Sensitivity

T cell recruitment to elicit contact sensitivity (CS) requires a CS-initiating process mediated by B-1 cells that produce IgM, which activates complement to promote T cell passage into the tissues. We now show that Vα14i NKT cells induce B-1 cell activation likely by releasing IL-4 early postimmuniz...

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Main Authors: Campos, Regis A., Szczepanik, Marian, Itakura, Atsuko, Akahira-Azuma, Moe, Sidobre, Stephane, Kronenberg, Mitchell, Askenase, Philip W.
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2003
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2194147/
https://ncbi.nlm.nih.gov/pubmed/14676294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20021562
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