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Activation of Natural Killer T Cells by α-Galactosylceramide Rapidly Induces the Full Maturation of Dendritic Cells In Vivo and Thereby Acts as an Adjuvant for Combined CD4 and CD8 T Cell Immunity to a Coadministered Protein

The maturation of dendritic cells (DCs) allows these antigen-presenting cells to initiate immunity. We pursued this concept in situ by studying the adjuvant action of α-galactosylceramide (αGalCer) in mice. A single i.v. injection of glycolipid induced the full maturation of splenic DCs, beginning w...

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Bibliografiske detaljer
Main Authors: Fujii, Shin-ichiro, Shimizu, Kanako, Smith, Caroline, Bonifaz, Laura, Steinman, Ralph M.
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2003
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2194082/
https://ncbi.nlm.nih.gov/pubmed/12874260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20030324
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