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Monocytes Heterozygous for the Asp299Gly and Thr399Ile Mutations in the Toll-like Receptor 4 Gene Show No Deficit in Lipopolysaccharide Signalling

Toll-like receptor 4 (TLR4)-mediated recognition of lipopolysaccharide (LPS) is required for efficient recognition of Gram-negative bacterial infections. Two commonly occurring mutations in the human TLR4 gene (Asp299Gly and Thr399Ile) have recently been shown to be associated with blunted physiolog...

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Sonraí Bibleagrafaíochta
Main Authors: Erridge, Clett, Stewart, John, Poxton, Ian R.
Formáid: Artigo
Teanga:Inglês
Foilsithe: The Rockefeller University Press 2003
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2193949/
https://ncbi.nlm.nih.gov/pubmed/12796470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20022078
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