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Stimulus-dependent Deacylation of Bacterial Lipopolysaccharide by Dendritic Cells

We describe here a previously unrecognized property of dendritic cells (DCs), the ability to deacylate the lipid A moiety of gram-negative bacterial LPSs. Both immature DCs of the XS52 cell line and bone marrow–derived DCs produce acyloxyacyl hydrolase, an enzyme that detoxifies LPS by selectively r...

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Detalhes bibliográficos
Main Authors: Lu, Mingfang, Zhang, Mei, Kitchens, Richard L., Fosmire, Susan, Takashima, Akira, Munford, Robert S.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2003
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2193946/
https://ncbi.nlm.nih.gov/pubmed/12810692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20030420
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