Potential Role of Phosphatidylinositol 3 Kinase, rather than DNA-dependent Protein Kinase, in CpG DNA–induced Immune Activation

Unmethylated CpG motifs present in bacterial DNA stimulate a strong innate immune response. There is evidence that DNA-dependent protein kinase (DNA-PK) mediates CpG signaling. Specifically, wortmannin (an inhibitor of phosphatidylinositol 3 kinase [PI3]-kinases including DNA-PK) interferes with CpG...

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Detalhes bibliográficos
Main Authors: Ishii, Ken J., Takeshita, Fumihiko, Gursel, Ihsan, Gursel, Mayda, Conover, Jacqueline, Nussenzweig, Andre, Klinman, Dennis M.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2002
Assuntos:
Brief Definitive Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2193923/
https://ncbi.nlm.nih.gov/pubmed/12119352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20020773
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