Nonredundant Roles for CD1d-restricted Natural Killer T Cells and Conventional CD4(+) T Cells in the Induction of Immunoglobulin E Antibodies in Response to Interleukin 18 Treatment of Mice

Interleukin (IL)-18 synergizes with IL-12 to promote T helper cell (Th)1 responses. Somewhat paradoxically, IL-18 administration alone strongly induces immunoglobulin (Ig)E production and allergic inflammation, indicating a role for IL-18 in the generation of Th2 responses. The ability of IL-18 to i...

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Détails bibliographiques
Auteurs principaux: Yoshimoto, Tomohiro, Min, Booki, Sugimoto, Takaaki, Hayashi, Nobuki, Ishikawa, Yuriko, Sasaki, Yuki, Hata, Hitomi, Takeda, Kazuyoshi, Okumura, Ko, Van Kaer, Luc, Paul, William E., Nakanishi, Kenji
Format: Artigo
Langue:Inglês
Publié: The Rockefeller University Press 2003
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2193873/
https://ncbi.nlm.nih.gov/pubmed/12695491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20021701
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