Treatment of Relapsing Paralysis in Experimental Encephalomyelitis by Targeting Th1 Cells through Atorvastatin

Statins, known as inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, exhibit numerous functions related to inflammation, such as MHC class II down-regulation, interference with T cell adhesion, and induction of apoptosis. Here we demonstrate that both subcutaneous and oral admi...

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Main Authors: Aktas, Orhan, Waiczies, Sonia, Smorodchenko, Alina, Dörr, Jan, Seeger, Bibiane, Prozorovski, Timour, Sallach, Stephanie, Endres, Matthias, Brocke, Stefan, Nitsch, Robert, Zipp, Frauke
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 2003
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2193848/
https://ncbi.nlm.nih.gov/pubmed/12629065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20021425
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