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Human T Cell Receptor γδ Cells Recognize Endogenous Mevalonate Metabolites in Tumor Cells

T lymphocytes expressing the T cell receptor (TCR)-γδ recognize unknown antigens on tumor cells. Here we identify metabolites of the mevalonate pathway as the tumor ligands that activate TCR-γδ cells. In tumor cells, blockade of hydroxy-methylglutaryl-CoA reductase (HMGR), the rate limiting enzyme o...

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Detalhes bibliográficos
Main Authors: Gober, Hans-Jürgen, Kistowska, Magdalena, Angman, Lena, Jenö, Paul, Mori, Lucia, De Libero, Gennaro
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2003
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2193814/
https://ncbi.nlm.nih.gov/pubmed/12538656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20021500
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