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The Inhibition of Arginase by N (ω)-Hydroxy-l-Arginine Controls the Growth of Leishmania Inside Macrophages

Polyamine synthesis from l-ornithine is essential for Leishmania growth. We have investigated the dependence of Leishmania infection on arginase, which generates l-ornithine, in macrophages from BALB/c, C57BL/6, and nitric oxide synthase II (NOS II)-deficient mouse strains. We have found that N (ω)-...

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Detalles Bibliográficos
Main Authors: Iniesta, Virginia, Gómez-Nieto, L. Carlos, Corraliza, Inés
Formato: Artigo
Idioma:Inglês
Publicado: The Rockefeller University Press 2001
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2193414/
https://ncbi.nlm.nih.gov/pubmed/11257143
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