Antiviral Cd8(+) T Cell Responses in Neonatal Mice: Susceptibility to Polyoma Virus–Induced Tumors Is Associated with Lack of Cytotoxic Function by Viral Antigen–Specific T Cells

Polyoma virus is a potent oncogenic pathogen when inoculated into newborn mice of particular H-2(k) strains. Using D(k) tetramers containing the dominant antipolyoma CD8(+) T cell epitope, middle T protein (MT)389–397, and intracellular interferon γ staining, we enumerated MT389-specific CD8(+) T ce...

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Hlavní autoři: Moser, Janice M., Altman, John D., Lukacher, Aron E.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 2001
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2193393/
https://ncbi.nlm.nih.gov/pubmed/11238590
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