Matrix Metalloproteinase 9 Protects Mice from Anti–Glomerular Basement Membrane Nephritis through Its Fibrinolytic Activity

Matrix metalloproteinase (MMP)9/gelatinase B is increased in various nephropathies. To investigate its role, we used a genetic approach. Adult MMP9-deficient (MMP9(−/)−) mice showed normal renal histology and function at 3 mo. We investigated the susceptibility of 3-mo-old mice to the accelerated mo...

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Bibliographic Details
Main Authors: Lelongt, Brigitte, Bengatta, Soraya, Delauche, Madeleine, Lund, Leif R., Werb, Zena, Ronco, Pierre M.
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2001
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2193369/
https://ncbi.nlm.nih.gov/pubmed/11283152
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