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The Binding Site of Human Adenosine Deaminase for Cd26/Dipeptidyl Peptidase IV: The Arg142gln Mutation Impairs Binding to Cd26 but Does Not Cause Immune Deficiency
Human, but not murine, adenosine deaminase (ADA) forms a complex with the cell membrane protein CD26/dipeptidyl peptidase IV. CD26-bound ADA has been postulated to regulate extracellular adenosine levels and to modulate the costimulatory function of CD26 on T lymphocytes. Absence of ADA–CD26 binding...
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| Hoofdauteurs: | , , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
The Rockefeller University Press
2000
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2193361/ https://ncbi.nlm.nih.gov/pubmed/11067872 |
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