Clonal Expansions of Cd8(+) T Cells Dominate the T Cell Infiltrate in Active Multiple Sclerosis Lesions as Shown by Micromanipulation and Single Cell Polymerase Chain Reaction

Clonal composition and T cell receptor (TCR) repertoire of CD4(+) and CD8(+) T cells infiltrating actively demyelinating multiple sclerosis (MS) lesions were determined with unprecedented resolution at the level of single cells. Individual CD4(+) or CD8(+) T cells were isolated from frozen sections...

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Detalhes bibliográficos
Main Authors: Babbe, Holger, Roers, Axel, Waisman, Ari, Lassmann, Hans, Goebels, Norbert, Hohlfeld, Reinhard, Friese, Michael, Schröder, Roland, Deckert, Martina, Schmidt, Stephan, Ravid, Rivka, Rajewsky, Klaus
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2000
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2193223/
https://ncbi.nlm.nih.gov/pubmed/10934227
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