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Modification of Cysteine Residues In Vitro and In Vivo Affects the Immunogenicity and Antigenicity of Major Histocompatibility Complex Class I–restricted Viral Determinants

In studying the subdominant status of two cysteine-containing influenza virus nuclear protein (NP) determinants (NP(39–47) and NP(218–226)) restricted by H-2K(d), we found that the antigenicity of synthetic peptides was enhanced 10–100-fold by treatment with reducing agents, despite the fact that th...

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Detalhes bibliográficos
Main Authors: Chen, Weisan, Yewdell, Jonathan W., Levine, Rodney L., Bennink, Jack R.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 1999
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2193077/
https://ncbi.nlm.nih.gov/pubmed/10359579
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