Microbial Epitopes Act as Altered Peptide Ligands to Prevent Experimental Autoimmune Encephalomyelitis

Molecular mimicry refers to structural homologies between a self-protein and a microbial protein. A major epitope of myelin basic protein (MBP), p87–99 (VHFFKNIVTPRTP), induces experimental autoimmune encephalomyelitis (EAE). VHFFK contains the major residues for binding of this self-molecule to T c...

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Auteurs principaux: Ruiz, Pedro J., Garren, Hideki, Hirschberg, David L., Langer-Gould, Annette M., Levite, Mia, Karpuj, Marcela V., Southwood, Scott, Sette, Alessandro, Conlon, Paul, Steinman, Lawrence
Format: Artigo
Langue:Inglês
Publié: The Rockefeller University Press 1999
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2193020/
https://ncbi.nlm.nih.gov/pubmed/10209044
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