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CD28 signals through acidic sphingomyelinase

T cell receptor recognition of antigen can lead either to T lymphocyte differentiation and proliferation or to a state of unresponsiveness, which is dependent on whether appropriate costimulatory signals are provided to the mature T cell. We have investigated a novel intracellular signaling pathway...

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Bibliographic Details
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 1995
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2192051/
https://ncbi.nlm.nih.gov/pubmed/7759998
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