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Facultative role of germinal centers and T cells in the somatic diversification of IgVH genes
The development of memory B cells takes place in germinal centers (GC) of lymphoid follicles where antigen-driven lymphocytes undergo somatic hypermutation and affinity selection, presumably under the influence of helper T cells. However, the mechanisms that drive this complex response are not well...
Gardado en:
| Formato: | Artigo |
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| Idioma: | Inglês |
| Publicado: |
The Rockefeller University Press
1995
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| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2191948/ https://ncbi.nlm.nih.gov/pubmed/7535332 |
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