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Circadian dynamics of tumor necrosis factor alpha (cachectin) lethality

Recombinant human tumor necrosis factor-alpha (TNF-alpha) has demonstrable antitumor activity in transplantable murine tumor models and patients with cancer but is highly toxic to both animals and human beings. The narrow therapeutic index of TNF-alpha has limited its anticancer utility. Toxicity as...

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Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 1994
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2191660/
https://ncbi.nlm.nih.gov/pubmed/8064225
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