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Characterization of the 2′,3′ cyclic phosphodiesterase activities of Clostridium thermocellum polynucleotide kinase-phosphatase and bacteriophage λ phosphatase

Clostridium thermocellum polynucleotide kinase-phosphatase (CthPnkp) catalyzes 5′ and 3′ end-healing reactions that prepare broken RNA termini for sealing by RNA ligase. The central phosphatase domain of CthPnkp belongs to the dinuclear metallophosphoesterase superfamily exemplified by bacteriophage...

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Autores principales: Keppetipola, Niroshika, Shuman, Stewart
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2007
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2190708/
https://ncbi.nlm.nih.gov/pubmed/17986465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkm868
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