Inhibition of 2-arachidonoylglycerol catabolism modulates vasoconstriction of rat middle cerebral artery by the thromboxane mimetic, U-46619

BACKGROUND AND PURPOSE: Cerebrovascular smooth muscle cells express the CB(1) cannabinoid receptor and CB(1) agonists produce vasodilatation of the middle cerebral artery (MCA). The thromboxane A(2) mimetic, U-46619, increased the content of the endocannabinoid, 2-arachidonoylglycerol (2-AG) in the...

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Detalhes bibliográficos
Main Authors: Hillard, C J, Ho, W-Sv, Thompson, J, Gauthier, K M, Wheelock, C E, Huang, H, Hammock, B D
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2007
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2190024/
https://ncbi.nlm.nih.gov/pubmed/17891162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0707468
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