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PTEN: a promising pharmacological target to enhance epithelial wound healing
PI3Ks (phosphoinositide-3 kinases) produce PIP3 (phosphatidylinositol(3,4,5)-trisphosphate) which mediates signals for cell survival and proliferation. The tumour suppressor PTEN (phosphatase and tensin homologue) dephosphorylates PIP3 and is a key negative regulator of PI3K signalling. Recent resea...
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| Autor principal: | |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2007
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2189987/ https://ncbi.nlm.nih.gov/pubmed/17922021 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0707503 |
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