Inhibitory effect of BIBN4096BS, CGRP(8–37), a CGRP antibody and an RNA-Spiegelmer on CGRP induced vasodilatation in the perfused and non-perfused rat middle cerebral artery

BACKGROUND AND PURPOSE: A new concept for the inhibition of CGRP signalling has been developed by interaction with the CGRP molecule per se by using a CGRP antibody or a CGRP binding RNA-Spiegelmer (NOX-C89). We have compared these CGRP scavengers with two known receptor antagonists (CGRP(8–37) and...

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Dettagli Bibliografici
Autori principali: Edvinsson, L, Nilsson, E, Jansen-Olesen, I
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2007
Soggetti:
Research Papers
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2189771/
https://ncbi.nlm.nih.gov/pubmed/17245362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0707134
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