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Sildenafil reduces L-NAME-induced severe hypertension and worsening of myocardial ischaemia–reperfusion damage in the rat

BACKGROUND AND PURPOSE: Phosphodiesterase-5 inhibitors are beneficial in pulmonary hypertension and congestive heart failure, the two conditions associated with coronary heart disease and ischaemia. We investigated whether sildenafil counteracts the cardiovascular alterations induced by N (ω)-nitro-...

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Detalhes bibliográficos
Main Authors: Rossoni, G, Manfredi, B, De Gennaro Colonna, V, Berti, M, Guazzi, M, Berti, F
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2189760/
https://ncbi.nlm.nih.gov/pubmed/17245365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0707131
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