Modulation of P2X(7) receptor functions by polymyxin B: crucial role of the hydrophobic tail of the antibiotic molecule

BACKGROUND AND PURPOSE: P2X(7) is a membrane receptor for extracellular ATP which is highly expressed in dendritic cells, macrophages and microglia where it mediates pro-inflammatory responses. The antibiotic polymyxin B, which binds to and neutralizes the toxic residue of bacterial lipopolysacchari...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Ferrari, D, Pizzirani, C, Gulinelli, S, Callegari, G, Chiozzi, P, Idzko, M, Panther, E, Di Virgilio, F
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group 2007
Gaiak:
Research Papers
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2189724/
https://ncbi.nlm.nih.gov/pubmed/17211459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0706994
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