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Functional heterogeneity of L3T4+ T cells in MRL-lpr/lpr mice. L3T4+ T cells suppress major histocompatibility complex-self-restricted L3T4+ T helper cell function in association with autoimmunity
The present study demonstrates in MRl-lpr/lpr autoimmune mice an age- dependent loss of MHC-self-restricted function by L3T4+ Th. This defect is not present in age-matched, congenic MRL-+/+ spleen cells and appears to be due to the presence of suppressor cells that are selective for L3T4+ Th and not...
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| Format: | Artigo |
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| Idioma: | Inglês |
| Publicat: |
The Rockefeller University Press
1988
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2189136/ https://ncbi.nlm.nih.gov/pubmed/2974064 |
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