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Clonotypic heterogeneity in experimental interstitial nephritis. Restricted specificity of the anti-tubular basement membrane B cell repertoire is associated with a disease-modifying crossreactive idiotype

Experimental anti-tubular basement membrane (anti-TBM) disease is an autoimmune interstitial nephritis elicited in susceptible rodents after immunization with renal tubular antigen. The nephritogenic antigen in the immunizing preparation is 3M-1, a 48,000 Mr noncollagenous glycoprotein. The hallmark...

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Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 1988
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2188927/
https://ncbi.nlm.nih.gov/pubmed/3128629
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