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Protection of bone marrow transplant recipients from lethal doses of methotrexate by the generation of methotrexate-resistant bone marrow
To develop a highly efficient means for generating methotrexate resistant (MTXr) hematopoietic cells in vivo, a recombinant retroviral genome was constructed that encodes a MTXr dihydrofolate reductase (DHFRr). Cell lines producing high titers of virus capable of transmitting the DHFR gene were gene...
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| Materialtyp: | Artigo |
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| Språk: | Inglês |
| Publicerad: |
The Rockefeller University Press
1987
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2188648/ https://ncbi.nlm.nih.gov/pubmed/3298524 |
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