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Invasion-inhibitory antibodies inhibit proteolytic processing of apical membrane antigen 1 of Plasmodium falciparum merozoites

Apical membrane antigen 1 (AMA-1) is a promising vaccine candidate for Plasmodium falciparum malaria. Antibodies against AMA-1 of P. falciparum (PfAMA-1) interrupt merozoite invasion into RBCs. Initially localized within the apical complex, PfAMA-1 is proteolytically processed and redistributed circ...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Dutta, Sheetij, Haynes, J. David, Moch, J. Kathleen, Barbosa, Arnoldo, Lanar, David E.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2003
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC218752/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14526103/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.2032858100
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