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Transition-path sampling of β-hairpin folding

We examine the dynamical folding pathways of the C-terminal β-hairpin of protein G-B1 in explicit solvent at room temperature by means of a transition-path sampling algorithm. In agreement with previous free-energy calculations, the resulting path ensembles reveal a folding mechanism in which the hy...

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Autor principal: Bolhuis, Peter G.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2003
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC218724/
https://ncbi.nlm.nih.gov/pubmed/14523242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1534924100
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