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An AMPK-FOXO pathway mediates the extension of lifespan induced by a novel method of dietary restriction in C. elegans

BACKGROUND: Dietary restriction (DR) is the most effective environmental intervention to extend lifespan in a wide range of species. However, the molecular mechanisms underlying the benefits of DR on longevity are still poorly characterized. AMP-activated protein kinase (AMPK) is activated by a decr...

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Bibliografiske detaljer
Main Authors: Greer, Eric L., Dowlatshahi, Dara, Banko, Max R., Villen, Judit, Hoang, Kimmi, Blanchard, Daniel, Gygi, Steven P., Brunet, Anne
Format: Artigo
Sprog:Inglês
Udgivet: 2007
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2185793/
https://ncbi.nlm.nih.gov/pubmed/17900900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2007.08.047
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