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An AMPK-FOXO pathway mediates the extension of lifespan induced by a novel method of dietary restriction in C. elegans
BACKGROUND: Dietary restriction (DR) is the most effective environmental intervention to extend lifespan in a wide range of species. However, the molecular mechanisms underlying the benefits of DR on longevity are still poorly characterized. AMP-activated protein kinase (AMPK) is activated by a decr...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2007
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2185793/ https://ncbi.nlm.nih.gov/pubmed/17900900 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2007.08.047 |
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