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Evidence for Segregation of Sphingomyelin and Cholesterol during Formation of Copi-Coated Vesicles

In higher eukaryotes, phospholipid and cholesterol synthesis occurs mainly in the endoplasmic reticulum, whereas sphingomyelin and higher glycosphingolipids are synthesized in the Golgi apparatus. Lipids like cholesterol and sphingomyelin are gradually enriched along the secretory pathway, with thei...

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Main Authors: Brügger, Britta, Sandhoff, Roger, Wegehingel, Sabine, Gorgas, Karin, Malsam, Jörg, Helms, J. Bernd, Lehmann, Wolf-Dieter, Nickel, Walter, Wieland, Felix T.
Formato: Artigo
Idioma:Inglês
Publicado: The Rockefeller University Press 2000
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2185577/
https://ncbi.nlm.nih.gov/pubmed/11062253
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