Characterization of mutationally altered dihydropteroate synthase and its ability to form a sulfonamide-containing dihydrofolate analog.

Among spontaneous mutants of Escherichia coli selected for resistance against sulfonamides, thermosensitive strains were found. These were shown to possess a changed dihydropteroate synthase (EC 2.5.1.15), which had a substantially higher Km value for its normal substrate, p-aminobenzoic acid, and a...

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Detaylı Bibliyografya
Asıl Yazarlar: Swedberg, G, Castensson, S, Sköld, O
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 1979
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC218426/
https://ncbi.nlm.nih.gov/pubmed/368012
Etiketler: Etiketle
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