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Characterization of mutationally altered dihydropteroate synthase and its ability to form a sulfonamide-containing dihydrofolate analog.

Among spontaneous mutants of Escherichia coli selected for resistance against sulfonamides, thermosensitive strains were found. These were shown to possess a changed dihydropteroate synthase (EC 2.5.1.15), which had a substantially higher Km value for its normal substrate, p-aminobenzoic acid, and a...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
Main Authors: Swedberg, G, Castensson, S, Sköld, O
פורמט: Artigo
שפה:Inglês
יצא לאור: 1979
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC218426/
https://ncbi.nlm.nih.gov/pubmed/368012
תגים: הוספת תג
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