Protein conjugates of synthetic saccharides elicit higher levels of serum IgG lipopolysaccharide antibodies in mice than do those of the O-specific polysaccharide from Shigella dysenteriae type 1

Our development of vaccines to prevent shigellosis is based on the hypothesis that a critical (protective) level of serum IgG to the O-specific polysaccharide (O-SP) domain of Shigella lipopolysaccharide (LPS) confers immunity. The O-SP is a hapten and must be conjugated to a protein to induce serum...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Pozsgay, Vince, Chu, Chiayung, Pannell, Lewis, Wolfe, Jennifer, Robbins, John B., Schneerson, Rachel
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1999
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC21840/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10220442/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.9.5194
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