Increased levels of dihydrofolate reductase in rifampin-resistant mutants of Bacillus subtilis.

Several independent, spontaneous rifampin-resistant mutants of Bacillus subtilis were isolated and found to have an increased resistance to trimethoprim, an inhibitor of dihydrofolate reductase. This increased resistance in the rif mutants was the result of a specific threefold increase in the activ...

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Veröffentlicht in:	J Bacteriol
Hauptverfasser:	Kane, J F, Wainscott, V J, Hurt, M A
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1979
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC218392/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/106041/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jb.137.2.1028-1030.1979
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