Desensitization of histamine H1 receptor-mediated inositol phosphate accumulation in guinea pig cerebral cortex slices.

1. Histamine stimulated the production of [3H]-inositol phosphates in untreated (control) guinea-pig cerebral cortex slices with a best-fit EC50 of 17 +/- 4 microM, and a best-fit maximum response of 385 +/- 23% over basal accumulation. 2. Histamine pretreatment desensitized guinea-pig cortex slices...

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Autores principales: Bristow, D. R., Banford, P. C., Bajusz, I., Vedat, A., Young, J. M.
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 1993
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2176030/
https://ncbi.nlm.nih.gov/pubmed/8106103
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