Inhibition of the ATP-sensitive potassium channel by class I antiarrhythmic agent, cibenzoline, in rat pancreatic beta-cells.

1. Cibenzoline, a class I antiarrhythmic agent, was investigated for its effect on the ATP-sensitive K+ channel of pancreatic beta-cells by the patch clamp technique. 2. In perforated patch clamp experiments, cibenzoline depolarized the membrane of single beta-cells and thereafter, caused firing of...

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Main Authors: Kakei, M., Nakazaki, M., Kamisaki, T., Nagayama, I., Fukamachi, Y., Tanaka, H.
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 1993
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2175729/
https://ncbi.nlm.nih.gov/pubmed/8401933
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