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Desensitization of histamine H1 receptor-mediated inositol phosphate production in HeLa cells.

1. Histamine stimulated the accumulation of total [3H]-inositol phosphates (IPn) in control HeLa cells with an EC50 of 3.7 +/- 0.7 microM in the presence of 10 mM LiCl. The maximum response to histamine after 15 min incubation was 43 +/- 5% over basal accumulation and occurred at a concentration of...

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Autors principals: Bristow, D. R., Zamani, M. R.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 1993
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2175704/
https://ncbi.nlm.nih.gov/pubmed/8358540
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