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Antiarrhythmic drugs, clofilium and cibenzoline are potent inhibitors of glibenclamide-sensitive K+ currents in Xenopus oocytes.

1. The novel K+ channel opener, Y-26763 induced outward K+ currents in voltage-clamped follicle-enclosed Xenopus oocytes in a concentration-dependent manner with an EC50 value of 58 microM. 2. The Y-26763-induced K+ current was completely and reversibly blocked by glibenclamide (an ATP-sensitive K+...

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Bibliografske podrobnosti
Main Authors: Sakuta, H., Okamoto, K., Watanabe, Y.
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 1993
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2175654/
https://ncbi.nlm.nih.gov/pubmed/8358576
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