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Effects of pH on the actions of dizocilpine at the N-methyl-D-aspartate receptor complex.

1. The effects of varying pH from 6.5 to 7.4 and 8.0 on the actions of dizocilpine (MK801) on the N-methyl-D-aspartate (NMDA) receptor were investigated by use of a [3H]-dizocilpine binding assay and NMDA-induced intracellular free Ca2+ ([Ca2+]i) increases in cultured forebrain neurones. 2. Increasi...

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Autors principals: Rajdev, S., Reynolds, I. J.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 1993
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2175603/
https://ncbi.nlm.nih.gov/pubmed/8495234
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