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The effect of lifarizine (RS-87476), a novel sodium and calcium channel modulator, on ischaemic dopamine depletion in the corpus striatum of the gerbil.

1. Unilateral ligation of the right common carotid artery in the anaesthetized gerbil for 3 h caused a 62.7% decrease in ipsilateral dopamine in the corpus striatum from 1.40 (+/- 0.13, n = 27) micrograms g-1 in the non-ischaemic hemisphere to 0.47 (+/- 0.07, n = 27) micrograms g-1 in the ischaemic...

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Detalles Bibliográficos
Main Authors: Brown, C. M., Calder, C., Alps, B. J., Spedding, M.
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 1993
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2175597/
https://ncbi.nlm.nih.gov/pubmed/8388296
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