Stimulation of insulin secretion and improvement of glucose tolerance in rat and dog by the P2y-purinoceptor agonist, adenosine-5'-O-(2-thiodiphosphate).

1. In vivo effect of a P2y-purinoceptor agonist, adenosine-5'-O-(2-thiodiphosphate) (ADP beta S), on insulin secretion and glycaemia were studied both in rats and dogs. 2. In anaesthetized rats, i.v. administered ADP beta S (0.2 mg kg-1) produced an insulin response dependent on the nutritional...

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Autores principales: Hillaire-Buys, D., Bertrand, G., Chapal, J., Puech, R., Ribes, G., Loubatières-Mariani, M. M.
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 1993
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2175573/
https://ncbi.nlm.nih.gov/pubmed/8495239
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