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An RNA targeted to the HIV-1 LTR promoter modulates indiscriminate off-target gene activation
Transcriptional gene silencing (TGS) can be achieved by small RNAs targeted to upstream promoter regions. Previously we characterized siRNAs targeted to the HIV-1 long terminal repeat (LTR) promoter at site 247, and found that a 21-base antisense strand of siRNA-247 (LTR-247as) suppressed LTR-mediat...
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Main Authors: | , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
Oxford University Press
2007
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2175361/ https://ncbi.nlm.nih.gov/pubmed/17959645 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkm847 |
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